Bioactive Small Molecules
Cayman Chemical Estroppate 5mg
A piperazine salt form of estrone 3-sulfate; inhibits OATP1B1 selectively over OATP1B3 (IC50s = 0.06 and 19.32 µM, respectively)
Medchemexpress LLC XP-524 | 2344825-52-9 | 98.02% | 552.65 | 25 MG
XP-524 is a potent BET and EP300 inhibitor, demonstrating significant tumoricidal activity in vivo. It prevents KRAS-induced neoplastic transformation and extends survival in aggressive PDAC transgenic mouse models. Additionally, it enhances the presentation of self-peptide and the recruitment of cytotoxic T lymphocytes, making it a promising compound for research into pancreatic ductal adenocarcinoma (PDAC).
- Potent BET and EP300 inhibitor
- Exhibits tumoricidal activity in vivo
- Prevents KRAS-induced neoplastic transformation
- Extends survival in PDAC mouse models
- Enhances self-peptide presentation
- Recruits cytotoxic T lymphocytes
Medchemexpress LLC 8-Aminoguanine | 28128-41-8 | 97.19% | 166.14 | 100 MG
8-Aminoguanine is an endogenous purine that inhibits purine nucleoside phosphorylase (PNPase) and induces diuresis, natriuresis, and glucosuria. This product is intended for research use only.
- Inhibits purine nucleoside phosphorylase (PNPase)
- Induces diuresis, natriuresis, and glucosuria
- Exhibits cellular effects on MOLT-4 cell line
![Medchemexpress LLC 2-[4-({[2-(benzodioxol-5-yloxy)pyridin-3-yl]carbonyl}amino)methyl]-3-fluorophenoxypropionic acid | 445295-04-5 | MFCD31382154 | 100.0% | 454.40 g·mol⁻1 | C23H19FN2O7 | 1 ML](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000248850.png-250.jpg)
Medchemexpress LLC 2-[4-({[2-(benzodioxol-5-yloxy)pyridin-3-yl]carbonyl}amino)methyl]-3-fluorophenoxypropionic acid | 445295-04-5 | MFCD31382154 | 100.0% | 454.40 g·mol⁻1 | C23H19FN2O7 | 1 ML
CP671305 is a potent, orally active, selective inhibitor of phosphodiesterase-4-D provided for research use. It is offered as a solid and as a ready-to-use 10 mM solution in DMSO (1 mL), and is characterized by high reported purity and documented physicochemical properties suitable for in vitro and in vivo studies.
- Potent, orally active selective phosphodiesterase-4-D inhibitor.
- Available as solid and as 10 mM solution in DMSO (1 mL).
- High reported purity (99.95%).
- Molecular weight 454.40 g·mol⁻1; formula C23H19FN2O7.
- Soluble in DMSO (~100 mg/mL) with ultrasonic assistance.
- Recommended storage: powder and solution conditions as specified.
Medchemexpress LLC HY-50878 100mg , Crizotinib CAS:877399-52-5 Purity:>98%
HY-50878 100mg Crizotinib CAS: 877399-52-5 Crizotinib (PF-02341066) is an orally bioavailable, ATP-competitive ALK and c-Met inhibitor with IC50s of 20 and 8 nM, respectively. Crizotinib inhibits tyrosine phosphorylation of NPM-ALK and tyrosine phosphorylation of c-Met with IC50s of 24 and 11 nM in cell-based assays, respectively. Crizotinib is also a ROS1 inhibitor. Crizotinib has effective tumor growth inhibition. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Cayman Chemical PDD00017273 5mg
A PARG inhibitor (IC50 = 26 nM in an enzyme assay); maintains persistence of nuclear PAR chains in HeLa cells in the presence of the DNA damaging agent MMS (IC50 = 37 nM); increases nuclear γH2AX intensity in MCF-7 cells in a concentration-dependent manner when used in combination with MMS; reduces clonogenic growth of ZR-75-1 and MDA-MB-436 cells but not HCC1937 cells (IC50s = 0.2, 0.8, and >10 μM, respectively)
Cayman Chemical 2- Phosphonmethyl-pentndI 5mg
A potent inhibitor of GCP II/NAALADase (Ki = 98 pM for release of glutamate from the NAALADase peptide substrate NAAG); selective for GCP II/NAALADase over a panel of 100 receptors, transporters, ion channels, and enzymes at a concentration of 10 μM; neuroprotective against hypoxia (EC50 = 8.4 μM) in neuron-enriched primary cultures from rat embryo cerebellum; reduces neuronal cell death induced by middle cerebral artery occlusion in rats; blocks the conditioned place preference response to cocaine in male rats (100 mg/kg); reduces the number of flinches induced by formalin injection into the footpad of mice (10 μg per animal); decreases severity and delays onset of EAE in mice
Cayman Chemical ANTIBODY LIpoxIn A4 50UG
A trihydroxy fatty acid containing a conjugated tetraene produced by the metabolism of (±)15-HETE or 15-HpETE with human leukocytes; promotes leukocyte activation, chemotaxis effects, natural killer cell inhibition, and monocyte migration and adhesion
![Medchemexpress LLC N-[(1R)-1-(3-amino-5-(trifluoromethyl)phenyl)ethyl]-7-methoxy-2-methylquinazolin-4-amine | 2230836-55-0 | MFCD32197204 | 100.0% | 462.46 g/mol | C23H25F3N4O3 | 25MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000236572.png-250.jpg)
Medchemexpress LLC N-[(1R)-1-(3-amino-5-(trifluoromethyl)phenyl)ethyl]-7-methoxy-2-methylquinazolin-4-amine | 2230836-55-0 | MFCD32197204 | 100.0% | 462.46 g/mol | C23H25F3N4O3 | 25MG
BI-3406 is a potent, selective, orally active small-molecule inhibitor of the SOS1-KRAS protein-protein interaction used as a research tool in oncology. It reduces formation of GTP-loaded RAS and limits proliferation in KRAS-driven cancer models; supplied as a white to off-white solid for laboratory use.
- Potent SOS1-KRAS interaction inhibitor with low-nanomolar activity.
- Suitable for biochemical and cellular assays.
- High chemical purity for research applications.
- Supplied as a white to off-white solid sample for laboratory use.
- Soluble in common organic solvents such as DMSO for assay preparation.
Cayman Chemical L-LeucIn-d10 5mg
An internal standard for the quantification of L-leucine by GC- or LC-MS
Cayman Chemical ANTIBODY QuazInon 25mg
A selective PDE3 inhibitor with positive inotropic and vasodilating properties; induces relaxation of precontracted isolated human cavernous smooth muscle (IC50 = 4.2 μM); increases myocardial contractile force in anesthetized open-chest dogs in a dose-dependent manner at 10-300 μg/kg, as well as decreases systolic and diastolic blood pressure; inhibits DNA synthesis induced by PDGF-BB in bovine coronary artery smooth muscle cells in a concentration-dependent manner
Cayman Chemical ANTIBODY PKSI-527 25mg
An inhibitor of plasma kallikrein (Ki = 0.81 μM); reduces bradykinin generation induced by kaolin and λ-carrageenan ex vivo in human plasma; prolongs partial thromboplastin and euglobulin clot lysis times; reduces hyperplasia, pannus formation, and infiltration of inflammatory cells in the tarsal joint of mice with collagen-induced arthritis
Medchemexpress LLC NADPH Oxidase 4 Antibody (YA4640) | 10 UL
NADPH Oxidase 4 Antibody (YA4640) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NADPH Oxidase 4. This antibody is affinity purified and supplied in a formulation of 10mM phosphate buffered saline, pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
- Rabbit-derived and non-conjugated IgG monoclonal antibody
- Targets NADPH Oxidase 4
- Affinity purified
- Stored at -20°C for 1 year; avoid repeated freeze/thaw cycles
TARGETMOL CHEMICALS INC MULBERROSIDE C 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. 1. Mulberroside C has antioxidant activity. purity: 99%
